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Negative immunohistochemical staining for (A) LAMA4 and (B) syndecan-4 in arthritic cartilage (dashed arrows) grade 0 according to the OARSI criteria for osteoarthritis. Only occasional cells in the surface layer show weak staining (+) (black arrows). Positive immunohistochemical staining (+++) for (C) LAMA4 and (D) syndecan-4 in arthritic cartilage lesions grade IV hypertrophic chondrocyte clusters according to the OARSI criteria for osteoarthritis (black arrows).
