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. 2015 Dec 2;10(12):e0143952. doi: 10.1371/journal.pone.0143952

Fig 1. Expression of M1- and M2- associated markers via qPCR following LD.

Fig 1

A: The number TUNEL+ photoreceptors increased profoundly after 24hrs LD. This number decreased progressively during the post-exposure period, though chronic levels of cell death remained after 7 days post-exposure. B: The expression of all M1 genes peaked at 24hrs LD, only to then diminish rapidly during the post-exposure period. Minimal up-regulation in these genes was observed after 7 days. C: M2-associated genes displayed more protracted up-regulation over the LD timecourse. Arginase and Igf1 expression had modest yet consistent up-regulation over time course. Prolonged up-regulation was also evident for CD206, Clec7a, and Lyve1 though with some temporal variation; CD206, Clec7a exhibited strong sustained up-regulation from 3 to 7 days post-exposure, while Lyve1 peaked at 3 days and was vastly reduced after 7. The overall trend in expression for each gene was significant by ANOVA (P < 0.05); N = 5 for each timepoint.