Table 3. Probabilities of the closed, open, and wide-open conformations of the BC-CT for WT and mutated insulin.
Insulin | Probability | ||
---|---|---|---|
Closed conformation | Open conformation | Wide-open conformation | |
WT | 0.64 | 0.31 | 0.05 |
Y26F | 0.66 | 0.34 | 0.00 |
Y26N | 0.15 | 0.62 | 0.23 |
Y26G | 0.07 | 0.05 | 0.88 |
Y26A | 0.06 | 0.31 | 0.63 |