Table 5. Agreement and HPV positivity for each collection method, overall (n = 130) and according to cytology results (n = 119).
| Cytology analysis | N. of Samples—Self-HPV* vs. Dr-WET | % Positive | Agreement (%) | Kappa (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | Self+/ Dr-WET+ | Self+/ Dr-WET - | Self-/ Dr-WET + | Self-/ Dr-WET - | Self-collection % (95% CI) | Dr-WET % (95% CI) | Overall | PPA | ||
| Overall | 130 | 85 | 23 | 0 | 22 | 83.1 (75.7–88.6) | 65.4 (56.9–73.0) | 82.3 | 88.1 | 0.56 (0.41–0.70) |
| NILM | 61 (51.3) | 34 | 12 | 0 | 15 | 75.4 (63.2–84.6) | 55.7 (43.3–67.5) | 80.3 | 85.0 | 0.58 (0.39–078) |
| ASC-US | 20 (16.8) | 15 | 3 | 0 | 2 | 90.0 (68.7–98.4) | 75.0 (52.8–89.2) | 85.0 | 90.9 | 0.50 (0.05–0.95) |
| AGC | 3 (2.5) | 1 | 1 | 0 | 1 | 66.7 (20.2–94.4) | 33.3 (56.3–79.8) | 66.7 | 66.7 | 0.40 (-0.37–1) |
| ASC-H | 9 (7.6) | 8 | 1 | 0 | 0 | 100 (65.5–100) | 88.9 (54.3–99.9) | 88.9 | 94.1 | 0 |
| LSIL | 20 (16.8) | 15 | 2 | 0 | 3 | 85.0 (63.1–95.6) | 75.0 (52.8–89.2) | 90.0 | 93.8 | 0.69 (0.31–1) |
| HSIL | 5 (4.2) | 5 | 0 | 0 | 0 | 100 (51.1–100) | 100 (51.1–100) | 100 | 100 | 1 |
| CC | 1 (0.8) | 0 | 1 | 0 | 0 | 100 (16.8–100) | 0 (0–83.3) | 0 | 0 | 0 |
| LSIL+ | 26 (21.8) | 20 | 3 | 0 | 3 | 88.5 (71.86.0) | 76.9 (56.0–89.0) | 89.7 | 93.0 | 0.61 (0.23–1) |
Abbreviations: Dr-WET = physician-collected samples using specimen transport medium; n = number; NILM = Negative for intraepithelial lesion or malignancy; ASC-US = Atypical squamous cells of undetermined significance; ASC-H = Atypical squamous cells-cannot rule out high grade; AGC = Atypical glandular cell; LSIL = Low-grade squamous intraepithelial lesion; LSIL+ = Low-grade squamous intraepithelial lesion or worse; HSIL = High-grade squamous intraepithelial lesion; CC = Cervical cancer; CI = confidence interval; PPA = Proportion of Positive Agreement.
*Comprises results from Self-HPV using both collection methods (s-DRY and s-FTA).