Table 2. Association of GFR-decline with serum CAF and additional clinical regressors.
| GFR decline at 1 year ≥ 1 ml/min/1.73m2 | ||||
|---|---|---|---|---|
| OR a | CI b | P-value | ||
| Model A | logCAF | 4.18 | 1.2–14.5 | 0.024* |
| eGFR T0 | 1.03 | 0.99–1.08 | 0.102 | |
| PU T0 | 1.0002 | 0.99–1.0006 | 0.299 | |
| Model B | logCAF | 4.15 | 1.14–15.07 | 0.031* |
| eGFR T0 | 1.03 | 0.99–1.08 | 0.109 | |
| RAAS-Block | 0.3 | 0.09–1.06 | 0.064 | |
| PU T0 | 1.0002 | 0.99–1.0006 | 0.321 | |
| Age | 1.001 | 0.93–1.07 | 0.964 | |
| BMI | 0.97 | 0.89–1.07 | 0.438 | |
| Model C | SCreat T0 | 6.3 | 0.8–50.29 | 0.079 |
| eGFR T0 | 1.05 | 0.98–1.12 | 0.104 | |
| RAAS-Block | 0.4 | 0.12–1.5 | 0.202 | |
| PU T0 | 1.0002 | 0.99–1.0006 | 0.348 | |
| Age | 1.020 | 0.95–1.009 | 0.554 | |
| BMI | 0.99 | 0.90–1.08 | 0.321 | |
a OR, odds ratio
b CI, 95% confidence interval
* Significance levels at 0.05
BMI, body mass index; eGFR T0, estimated GFR assessed by the CKD-EPI formula at baseline; PU T0, Proteinuria assessed by protein to creatinine ratio at baseline; logCAF, serum CAF levels (log-transformed). GFR, estimated glomerular filtration rate; SCreat, Serum creatinine; renin-angiotensin-aldosterone system blockade (RAAS-Block).