Fig 1. Stereo views of the TSVZV and TSHS active sites.
Corresponding stereo views of the ligands and amino acids lining the TS active sites in the structures of (a) apo-TSVZV with a phosphate ion, (b) TSVZV with dUMP, (c) TSHS with dUMP (PDB ID: 1HVY) [35] and (d) TSVZV with BVDUP. The polar interactions between the amino acids and the different ligands are illustrated by orange dotted lines. 2F0-FC electron densities of the binding (e) BVDUP and (f) dUMP with the surrounding hydrophobic amino acids are also shown (contoured at 1σ with carved = 2.0).