Table 2.
Correlates of hepatic and peripheral insulin sensitivity
Variable | % Suppression of EGP |
Rd-low |
M/I-low |
M/I-high |
||||
---|---|---|---|---|---|---|---|---|
White | Black | White | Black | White | Black | White | Black | |
Body composition | ||||||||
Body fat (kg) | 0.08 | –0.64* | –0.09 | –0.34 | 0.01 | –0.64* | 0.12 | –0.60* |
Waist | 0.09 | –0.65** | –0.18 | –0.73** | –0.25 | –0.67** | –0.44 | –0.73* |
VAT | –0.04 | –0.52* | –0.20 | –0.35 | –0.34 | –0.62* | –0.62* | –0.30 |
SAT | 0.19 | –0.54* | –0.21 | –0.26 | 0.13 | –0.45 | 0.17 | –0.50* |
Ectopic fat | ||||||||
Liver fat | 0.28 | –0.57* | –0.44 | –0.41 | –0.45 | –0.34 | –0.53 | –0.21 |
Soleus IMCL | 0.59* | –0.46 | –0.16 | –0.52 | 0.12 | –0.62* | –0.08 | –0.46 |
Soleus fat (%) | 0.34 | –0.56* | –0.04 | –0.40 | 0.27 | –0.66* | 0.09 | –0.33 |
Muscle gene expression | ||||||||
IRS | –0.32 | 0.49 | 0.04 | 0.65* | –0.15 | 0.56* | –0.37 | 0.66* |
VAMP | –0.37 | 0.43 | –0.07 | 0.68** | –0.18 | 0.52 | –0.49 | 0.64* |
SCD1 | –0.33 | 0.49 | –0.03 | 0.90** | –0.23 | 0.53 | –0.29 | 0.72** |
Circulating adipokines | ||||||||
Adiponectin | 0.41 | 0.49 | 0.47 | 0.77** | 0.64** | 0.56* | 0.75** | 0.71** |
Values are Pearson correlation coefficients
p<0.05
p<0.01
M/I-high, M/I corrected for circulating insulin levels during the high-dose (40 mU m–2 min–1) clamp; M/I-low, M/I corrected for circulating insulin levels during the low-dose clamp; Rd-low, Rd during the low-dose (10 mU m–2 min–1 )clamp