Figure 7.

Schematic models for Aβ oligomerization through interactions between the core β-hairpin structures. Two arrows in each molecule represent two β-strands, connected by a loop or turn. The monomers are colored gray and pink, and the isotopically labeled segments are indicated by darker color. In all cases, the structures are stabilized by intramolecular H-bonding and intermolecular non-H-bonding contacts, i.e. ionic and/or hydrophobic interactions. The plane of the picture is parallel to the hairpin plane. In a) and b), the aggregation axis is perpendicular, and in c) to f) it is coplanar to the picture plane.