Table 2.
Summary of mutations in targeted gene panel
| Gene | Guat. | % | Venez. CIN | % | Venez. CC | % | Mexico | % | Total |
|---|---|---|---|---|---|---|---|---|---|
| PIK3CA | 91/280 | 33% | 2/30 | 7% | 11/40 | 28% | 91/325 | 28% | 30% |
| TP53 | 15/280 | 5.4% | 0/30 | 0% | 2/40 | 5% | 15/325 | 5% | 5.0% |
| STK11 | 11/280 | 3.9% | 0/30 | 0% | 2/40 | 5% | 6/325 | 2% | 2.9% |
| PTEN | 14/280 | 5.0% | 0/24 | 0% | 2/40 | 5% | 22/325 | 7% | 5.9% |
| KRAS | 2/280 | 0.7% | 0/24 | 0% | 1/40 | 3% | 12/325 | 4% | 2.3% |
| HRAS | 2/280 | 07% | 0/24 | 0% | 0/40 | 0% | 5/325 | 2% | 1.1% |
| CDKN2A | 0/280 | 0% | 1/24 | 3% | 1/40 | 32% | 0/325 | 0% | 0.2% |
| CTNNB1 | 0/280 | 0% | 1/24 | 3% | 1/40 | 3% | 0/325 | 0 | 0.2% |
| PIK3CA+PTEN | 105/280 | 38% | 13/40 | 33% | 108/325 | 33% | 35% | ||
| All PI3K | 111/280 | 40% | 15/40 | 38% | 104/325 | 32% | 36% |
Mutations in targeted genes are shown for each country along with the percentage and sum of PIK3CA and PTEN (PIK3CA+PTEN) and PIK3CA< PTEN and STK11 (All PI3K). CIN, cervical intraepithelial neoplasia; CC, cervical cáncer, Guat., Guatemala, Venez., Venezuela. Total excludes Venezuela CIN.