Table 1.
Baseline Characteristics of patients in the STICH trial with and without diabetes
| Variable | Diabetes (n=489) |
No Diabetes (n=723) |
P |
|---|---|---|---|
| Demographics | |||
| Age (yrs.) | 60.5 (55.0, 67.6) | 58.9 (52.7, 66.8) | 0.005 |
| Female gender | 17.2% | 8.9% | <0.001 |
| Race-White | 67.9% | 68.5% | 0.834 |
| BMI | 27.4 (24.4, 30.8) | 26.4 (23.7, 29.4) | <0.001 |
| Medical History | |||
| Previous MI | 71.2% | 81.1% | <0.001 |
| Previous stroke | 9.8% | 6.1% | 0.016 |
| Hypertension | 67.3% | 55.2% | <0.001 |
| Hyperlipidemia | 64.2% | 57.7% | 0.023 |
| Peripheral vascular disease |
16.8% | 14.1% | 0.205 |
| Chronic renal insufficiency |
12.5% | 4.6% | <0.001 |
| Atrial fibrillation/flutter |
11.7% | 13.3% | 0.404 |
| Cancer in last 5 yrs. | 1.6% | 0.8% | 0.198 |
| Current smoker | 17.6% | 23.0% | 0.023 |
| Depression | 7.4% | 5.5% | 0.198 |
| Previous CABG | 2.9% | 3.0% | 0.856 |
| Previous PCI | 13.1% | 12.7% | 0.853 |
| ICD | 3.1% | 1.9% | 0.206 |
| Pacemaker for heart rate |
2.5% | 0.8% | 0.022 |
|
Presenting characteristics |
|||
| CCS angina class | 0.059 | ||
| No angina | 41.7% | 32.9% | |
| I | 12.9% | 17.2% | |
| II | 39.1% | 46.2% | |
| III | 4.9% | 3.3% | |
| IV | 1.4% | 0.4% | |
| Current NYHA Class |
0.564 | ||
| I | 12.1% | 11.1% | |
| II | 49.9% | 52.8% | |
| III | 33.9% | 34.0% | |
| IV | 4.1% | 2.1% | |
| Systolic blood pressure (mmHg) |
120 (110, 130) | 120 (110, 130) | 0.189 |
| Pulse (bpm) | 75 (67, 84) | 72 (65, 80) | <0.001 |
| Labs | |||
| Hemoglobin (g/dL) | 13.4 (12.2, 14.6) | 14.1 (13.0, 15.1) | <0.001 |
| Creatinine (mg/dL) | 1.1 (0.9, 1.3) | 1.1 (1.0, 1.2) | 0.642 |
| Sodium (mEg/L) | 139 (136, 141) | 140 (138, 142) | <0.001 |
| BUN (mg/dL) | 23 (16, 36) | 22 (16, 38) | 0.959 |
| Medication use at baseline |
|||
| Beta blocker | 85.1% | 85.8% | 0.741 |
| ACEi or ARB | 90.2% | 89.1% | 0.536 |
| Statin | 82.4% | 80.2% | 0.339 |
| Digoxin | 26.4% | 16.0% | <0.001 |
| Aspirin | 83.0% | 82.4% | 0.789 |
| Warfarin | 10.8% | 10.2% | 0.737 |
| Clopidogrel | 21.9% | 14.0% | <0.001 |
| Loop diuretic | 72.0% | 60.8% | <0.001 |
ACEi – angiotensin converting enzyme inhibitor; ARB – angiotensin receptor blocker BMI – body mass index; BUN – blood urea nitrogen; CABG – coronary artery bypass grafting; CCS – Canadian Classification Score; ICD – implantable cardioverter defibrillator; MI – myocardial infarction; NYHA – New York Heart Association; PCI – percutaneous coronary intervention