Table 2. Genes causally related to liver cancer with mutated alleles expressed at the protein level.
| Symbol | Effects | Reference |
|---|---|---|
| HNF1A | Down regulation of human HNF1A mRNA in HCC is associated with HCC in human | 43 |
| An potent inhibitive effect of HNF1α on HCC by inducing the differentiation of hepatoma cells into mature hepatocytes and G(2)/M arrest | 14 | |
| FAH | Homozygous mutant mouse Fah increases incidence of HCC in mouse | 18,19 |
| GNMT | GNMT is involved in growth of HCC | 20 |
| Homozygous mutant mouse Gnmt increases incidence of HCC | 22 | |
| SPTBN1 | Heterozygous mutant mouse Sptbn1 gene increases incidence of HCC in mouse | 24,25 |
HCC, hepatocellular carcinoma.