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. 2015 Dec 3;5:17655. doi: 10.1038/srep17655

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Copyright © 2015, Macmillan Publishers Limited

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(a) Analysis of B cell phenotype in Sec13^+/+ and Sec13^H/− mice. Cell subsets isolated from spleen and mesenteric lymph nodes (MLN) were analyzed by flow cytometry using B220+ CD19+ as phenotypic markers for B lymphocytes. B1 cells were identified as either B220+CD19+CD5+ or CD19+CD5+CD1d+. The activation state of B cells was studied using CD23, CD138 as markers; B cell survival was analyzed using BAFF-R and CD95 as markers. Results are the mean +/− SD (n = 8). Data are representative of three independent experiments. Student T test was applied. *Statistically different p < 0.05. (b–d) Immunoglobulin levels were determined in sera of Sec13^+/+ and Sec13^H/− mice by ELISA. Results are the mean +/− SD (n = 8). Data are representative of three independent experiments.