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. 2015 Dec 3;5:17673. doi: 10.1038/srep17673

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Copyright © 2015, Macmillan Publishers Limited

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The conduction process and neuronal activities evoked by painful stimulation were recorded in the thalamus and after the injection of a tracer (Gd-DTPA), which did not interfere with the thalamic recordings. (A,B) The neuronal responses of anesthetized rats during electrical stimulation before and after Gd-DTPA injection. (C,D): The neuronal responses during electrical stimulation in the awake state before and after Gd-DTPA injection. (E,F) The statistical analyses of (A–D). Similar neuronal spikes were detected before and after Gd-DTPA injection. Furthermore, awake rats were more sensitive than anesthetized rats to stimulation.