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. Author manuscript; available in PMC: 2015 Dec 3.
Published in final edited form as: Drug Discov Today. 2015 Jun 16;20(10):1169–1175. doi: 10.1016/j.drudis.2015.06.001

Table 2. Cytokine biomarkers and target cells of various diseases.

Asthma/airway inflammation Cardiovascular disease Cancer and malignancy Rheumatoid arthritis
Cytokine biomarkers
Eotaxin; GM-CSF; IFNγ; IL-4, -5, -8, -10, -12, -13, -17A, -17F, -18; TNFα CCL2 (MCP-1); CCL3 (MIP-1α); CCL4 (MIP-1β); CRP; CSF; CXCL16; erythropoietin; FGF; fractalkine (CX3CL1); G-CSF; GM-CSF; IFNγ; IL-1, -2, -5, -6, -8, -8 (CXCL8), -10, -15, -18; M-CSF; PDGF; RANTES (CCL5); TNFα; VEGF Eotaxin; GM-CSF; IFNγ; IL-4, -5, -8, -10, -12, -13, -17A, -18; TNFα IL-1β, -1RA, -6,-7,-10–12,-15,-17, -18,-23; MIP-3α; TGFβ; TNFα
Target cells
TH2, B cells, dendritic cells, mast cells, basophils, eosinophils, airway epithelial cells Monocytes and/or macrophages, T cells, vascular endothelial cells T cells, regulatory T cells, natural killer cells, dendritic cells, macrophages, cancer stem cells TH1, TH17, B cells, neutrophils, monocytes and/or macrophages, synoviocytes