Table 1.
Pharmacokinetic parameters obtained from plasma concentrations after administration of marbofloxacin in infected neutropenic mice
| Marbofloxacin dose (mg/kg) | Cmax mean ± SD (μg/ml) | Tmax (h) | AUC (μg.h/ml) | Cl (ml kg−1 h−1) | T1/2 (h) |
|---|---|---|---|---|---|
| 1.25 | 0.66 ± 0.07 | 0.75 | 2.92 | 411.2 | 5.40 |
| 2.5 | 1.14 ± 0.14 | 0.75 | 5.73 | 420.3 | 5.23 |
| 5 | 2.13 ± 0.22 | 0.75 | 12.05 | 400.9 | 5.00 |
| 10 | 4.83 ± 0.30 | 0.75 | 23.90 | 408.9 | 4.29 |
Cmax: maximum concentration of drug in plasma
Tmax: time to maximum concentration of drug in plasma
AUC: area under the concentration-time curve
Cl: clearance
T1/2: half-life