Table 2.
Treatment group and time point | Total dose (mg/kg) | Bacterial population (mean ± SD) (log10 CFU/lung) |
---|---|---|
Untreated controls | 0 | |
At start of treatmenta | 7.12 ± 0.12 | |
24 h after inoculationb | 9.07 ± 0.19 | |
24 h after start of treatment | ** | |
Single administration | 0.625 | 7.79 ± 0.56 |
1 | 6.87 ± 0.91 | |
1.25 | 6.31 ± 0.74 | |
2 | 5.20 ± 0.74 | |
2.5 | 4.97 ± 0.52 | |
4 | 4.88 ± 0.41 | |
5 | 4.14 ± 0.49 | |
8 | 3.64 ± 0.63 | |
10 | 3.40 ± 0.32 |
aTotal bacterial population 10 h after the time of infection
b24 h after the inoculation was the time that the mice approached to death, and the lungs were removed for calculation the bacterial population
**The mice were already dead