Table 2.
Genome-wide significant results for FEV1/FVC in the meta-analysis. The SNP with the lowest p value within each region or gene is listed ordered by chromosome number
| SNP | Position (bp) | CHR | Nearest Gene | Coded Allele | COPDGene NHW | COPDGene AA | Meta-Analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele Freq | Beta | P | Allele Freq | Beta | P | Allele Freq | Beta | P | |||||
| rs72738834 | 218623888 | 1 | TGFB2 | G/G/A | 0.79 | −0.01 | 0.00276 | 0.834 | −0.017 | 5.34E-05 | 0.81 | −0.013 | 6.51E-09 |
| rs6837671 | 89873092 | 4 | FAM13A | G/G/A | 0.60 | −0.01 | 5.18E-06 | 0.416 | 0.007 | 0.03196 | 0.535 | 0.013 | 5.45E-13 |
| rs13141641 | 145506456 | 4 | LOC646576 (near HHIP) | C/C/T | 0.60 | −0.02 | 5.72E-09 | 0.888 | −0.015 | 0.00477 | 0.632 | −0.018 | 9.52E-20 |
| rs72981684 | 102724211 | 11 | MMP12 | T/T/T | 0.88 | −0.02 | 2.46E-07 | 0.968 | −0.024 | 0.02783 | 0.114 | 0.019 | 3.92E-10 |
| rs72981675 | 102721251 | 11 | MMP3 | T/T/T | 0.88 | −0.02 | 2.80E-07 | 0.968 | −0.024 | 0.02842 | 0.114 | 0.019 | 3.65E-10 |
| rs754388 | 93115410 | 14 | RIN3 | G/G/C | 0.82 | −0.02 | 3.17E-07 | 0.85 | −0.01 | 0.00898 | 0.83 | −0.014 | 5.54E-09 |
| rs56077333 | 78899003 | 15 | CHRNA3 | A/A/A | 0.65 | −0.02 | 4.70E-10 | 0.816 | 0.019 | 6.02E-06 | 0.314 | −0.018 | 9.55E-20 |
| rs8042849 | 78817929 | 15 | AGPHD1 | C/C/T | 0.56 | 0.02 | 2.71E-10 | 0.568 | 0.008 | 0.02729 | 0.561 | 0.015 | 2.81E-15 |
| rs17486278 | 78867482 | 15 | CHRNA5 | C/C/A | 0.63 | 0.02 | 2.28E-09 | 0.709 | 0.016 | 3.14E-06 | 0.65 | 0.017 | 4.48E-20 |
| rs58365910 | 78849034 | 15 | PSMA4 | C/C/T | 0.628 | 0.016 | 2.28E-09 | 0.747 | 0.011 | 0.00475 | 0.655 | 0.015 | 1.24E-15 |
| rs17487223 | 78923987 | 15 | CHRNB4 | G/T/T | 0.616 | 0.016 | 9.73E-09 | 0.882 | 0.013 | 0.00999 | 0.349 | −0.016 | 3.28E-15 |
| rs17484524 | 78772676 | 15 | IREB2 | G/G/A | 0.639 | 0.015 | 1.86E-07 | 0.936 | 0.01 | 0.138 | 0.666 | 0.015 | 4.83E-13 |
| rs12913260 | 79071095 | 15 | ADAMTS7 | A/A/A | 0.59 | 0.02 | 1.60E-05 | 0.88 | 0.004 | 0.53 | 0.371 | −0.015 | 4.82E-08 |
| rs56113850 | 41353107 | 19 | CYP2A6 | T/C/T | 0.60 | −0.02 | 2.46E-05 | 0.562 | 0.01 | 0.01955 | 0.462 | 0.014 | 5.19E-09 |
The “Coded Allele” column refers to the reference allele where the first reference allele is for the COPDGene NHW cohort, the second reference allele is for the COPDGene AA cohort, and the third reference allele is for the meta-analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS. Note that FEV1/FVC was measured on the proportion scale (0–1) and not the percentage scale (0–100)