Table 2.
Detection of HSE in TFs up-regulated during response of the genome to misfolded myosin
| Name | Cluster | Padj | Hsf1 sequence | Position | 24-hpf expression | Human ChIP peak |
|---|---|---|---|---|---|---|
| CREB3L3 | 1 | 4.9E-15 | TCTCCAGAAACATCC | 1973–1987 (intron) | Not restricted | Yes |
| myod1 | 1 | 1.5E-04 | GTTCTGGAACATTAC | 1658–1672 (exon1) | Somite | No |
| mxtx1 | 1 | 1.6E-05 | TTTCAAGAAATTTCT | 574–588 (promoter) | Not restricted | No ortholog |
| zgc:113263 | 1 | 4.9E-05 | CTTCCTGAAGTTTCG | 659–673 (promoter) | Not restricted | No ortholog |
| atf5b | 4 | 1.4E-04 | TTTCTAGAGACTTCC | 1295–1309 (intron) | NA | Yes |
| nfe2l1 | 4 | 2.3E-05 | TTTCCAGAATATTTT | 876–890 (promoter) | Not restricted | Yes |
| AL929286.1 | 4 | 8.5E-17 | TGTCCAGCACCTTCT | 1278–1292 (exon1) | NA | No ortholog |
| znf395a | 4 | 5.1E-34 | TTTCTAGAACATTAT | 178–192 (promoter) | Not restricted | No |
| TTTCTAAAACATTCC | 1880–1894 (intron) | |||||
| tfe3a | 4 | 3.1E-06 | TTTGCAGAATCTTCC | 250–264 (promoter) | Blood, YSL, lens | No |
| stat5.1 | 6 | 1.4E-02 | ATTCCGGAAGCTTCT | 341–355 (promoter) | Somite | Yes |
| tcf3 | 6 | 4.3E-03 | TCTCTGGCAAATTCT | 328–342 (promoter) | Not restricted | Yes |
| hoxc1a | 6 | 1.5E-02 | CTTTCAGAACTTTCT | 1359–1373 (exon1) | Spinal cord | Yes |
| klf15 | 6 | 7.3E-03 | TTTCCAGAATTTTTT | 330–344 (promoter) | Somite | Yes |
| neurog1 | 6 | 2.2E-02 | TTTCTGGCGTATTCC | 1180–1194 (intron) | Nervous system | Yes |
| vox | 6 | 4.5E-02 | TTTCTGAAATATTCT | 1550–1564 (intron) | Not restricted | No |
| sim1a | 6 | 3.6E-02 | TTTCTTGAAGTCTCT | 957–971 (promoter) | Diencephalon | No |
| TATCCAGAAGGATCT | 986–1000 (promoter) | |||||
| znf800b | NA | 5.1E-03 | TTTCCAGAAGAGTCG | 638–652 (promoter) | NA | Yes |
| tefa | NA | 8.2E-04 | CTTCCAGAAGATTCG | 1289–1303 (exon2) | Not restricted | Yes |
| znfl2a | NA | 9.9E-02 | TTTCTAGCTCTTTCT | 827–841 (promoter) | Blood | No ortholog |
The 19 TFs up-regulated during the misfolded myosin response with identified Hsf1 binding sites. Position of the potential Hsf1 binding site (p values are indicated) relative to the transcriptional start site is indicated with a reference to promoter, exonic and intronic location in parentheses. Data from RNAseq (clusters obtained by fuzzy mean clustering), expression patterns observed at 24 hpf [43], as well as HSF1 occupancy from human orthologs obtained from ChIP are indicated, if available. NA not available