Fig. 1.

Schematic of nucleotide metabolism and transport pathways in P. falciparum. a Enzymes required for the metabolism of pyrimidine nucleosides to nucleotides for incorporation into DNA. Plasmodium species lack thymidine kinase but contain all the other enzymes shown downstream. b Schematic showing the route by which modified nucleosides like BrdU could enter intra-erythrocytic parasites. RBC red blood cell, PfNT1 P. falciparum nucleoside transporter 1