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. 2015 Dec 3;15:251. doi: 10.1186/s12883-015-0500-4

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© Tu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Single-photon emission computed tomography (SPECT) correlates with clinical presentations and disease severity of cobalamin-deficient patients. (a) A case with anxiety disorder but preserved cognition. Clinical Dementia Rating (CDR) = 0. SPECT shows hypoperfusion in right basal ganglia (asterisk) and bilateral temporal tips (arrow heads; Patient #12). (b) A case with prominent dysexecutive syndrome. CDR = 0.5. SPECT shows hypoperfusion in right basal ganglia (asterisk) and left dorsolateral prefrontal cortex, in addition to temporal regions. (arrow heads; Patient #4). (c) A case with clinical diagnosis of dementia. CDR = 1. SPECT shows bilateral, more pronounced in the left, thalamus (asterisk) and fronto-temporal regions hypoperfusion (arrow heads; Patient #1)