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. 2015 Dec 3;15:251. doi: 10.1186/s12883-015-0500-4

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© Tu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Single-photon emission computed tomography (SPECT) signal changes in relation to cobalamin replacement therapy. (a) A demented patient with no improvement in cognition after therapy [Mini-Mental State Examination (MMSE) = 12 to 11] had minimal signal regain only within temporal regions. (arrow heads; Patient #1) (b) A mildly cognitive impaired patient with improvement in cognition after therapy (MMSE = 24 to 28) had avid SPECT signal recovery within bilateral fronto-temporal regions.(arrow heads; Patient #3) (c) A patient with improvement of initial dysexecutive complaints and anxiety after therapy (MMSE = 28 to 30) had improving signals within bilateral thalamus (asterisk) and fronto-temporal regions.(arrow heads; Patient #7) (d) A mildly cognitive impaired patient with improvement in cognition after therapy (MMSE = 27 to 29) had improving perfusion within bilateral thalamus (asterisk) and temporal regions from the follow-up SPECT. (arrow heads; Patient #8)