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Multivariate analysis of prognostic factors of pancreatic neuroendocrine tumors
| Variable | Hazard ratio | (95% CI) | P value |
|---|---|---|---|
| Ki-67 index (>10 vs ≤10%) | 38.8 | (8.42–226.62) | <0.001 |
| Previous curative resection (yes vs no) | 1.29 | (0.40–4.63) | 0.673 |
| No. of disease sites (≥3 vs 1–2) | 1.12 | (0.32–4.05) | 0.863 |
| Bone metastases (yes vs no) | 5.66 | (1.10–24.00) | 0.039 |
| Hormonal production (yes vs no) | 2.68 | (0.98–7.62) | 0.054 |
| Treatment timing (after vs before targeted therapies) | 0.02 | (0.00–0.11) | <0.001 |
