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. Author manuscript; available in PMC: 2016 Mar 10.
Published in final edited form as: J Control Release. 2015 Oct 23;219:181–191. doi: 10.1016/j.jconrel.2015.10.009

Fig. 3.

Fig. 3

Active targeting of oncolytic Ad/polymers. Active targeting strategy. Ligands grafted at the surface of polymers, which complexed with oncolytic Ad, bind to receptors overexpressed cancer cells. After endocytosis, Ad/polymer enters into the endosome, then escape from endosome when pH value of endosome becomes acidic.