Table 2. Results of the model sensitivity analysis.
| Sensitivity | Activation time (Tact) | |||||
|---|---|---|---|---|---|---|
| TNF-α | IL-1β | IL-6 | IL-10 | Ntot | Mtot | |
| Highest | 1 (2,774) | 1 (2,724) | 1 (3,039) | 1 (2,470) | 1 (4,035) | 1 (4,681) |
| 2nd highest | 13 (1,887) | 13 (1,250) | 13 (1,635) | 13 (1,135) | 13 (3,769) | 13 (3,102) |
| 3rd highest | 2 (839) | 22 (624) | 2 (785) | 2 (610) | 2 (371) | 2 (371) |
| Peak height (Ψ max ) | ||||||
| TNF-α | IL-1β | IL-6 | IL-10 | N tot | M tot | |
| Highest | 19 (6,081) | 22 (3,560) | 7 (7,725) | 7 (6,948) | 3 (9,766) | 7 (8,960) |
| 2nd highest | 17 (2,846) | 7 (3,243) | 23 (1,282) | 28 (1,783) | 1 (66) | 1 (342) |
| 3rd highest | 7 (404) | 20 (1,842) | 1 (284) | 1 (355) | 13 (35) | 13 (233) |
| Resolution interval (R i ) | ||||||
| TNF-α | IL-1β | IL-6 | IL-10 | N tot | M tot | |
| Highest | 10 (1,573) | 10 (2,369) | 1 (1,441) | 10 (2,454) | 1 (2,321) | 10 (3,481) |
| 2nd highest | 1 (1,146) | 1 (913) | 10 (1,009) | 1 (984) | 13 (1,412) | 1 (1,025) |
| 3rd highest | 7 (1,004) | 13 (755) | 13 (813) | 13 (624) | 7 (790) | 13 (592) |
| Resolution plateau (R p ) | ||||||
| TNF-α | IL-1β | IL-6 | IL-10 | N tot | M tot | |
| Highest | 10 (8,753) | 10 (9,205) | 10 (8,994) | 10 (9,724) | 7 (2,203) | 10 (9,805) |
| 2nd highest | 1 (284) | 1 (162) | 1 (221) | 13 (32) | 5 (2,092) | 1 (23) |
| 3rd highest | 7 (178) | 13 (117) | 13 (112) | 1 (31) | 10 (1,426) | 13 (17) |
In each cell, the entry without parentheses represents the assigned number (P#) of a particular model parameter, and the entry in parentheses represents the number of simulations (out of the total 10,000 simulations) for which the sensitivity of the indicated inflammation index (corresponding to the indicated model output variable) with respect to this parameter (see Eq 1) was the highest, 2nd highest, and 3rd highest across all 69 model parameters.