Table 2. TMT Scores and MRI measurements of All Participants According to CKD Stages.
Abbreviations: CSFV, cerebrospinal fluid volume; GMV, gray matter volume; TICV, total intracranial volume; TMT, Trail Making Test; WMV, white matter volume.
| All participants (n = 95) | CKD stage 3a (n = 34) | CKD stage 3b (n = 26) | CKD stages 4+5 (n = 35) | P for trend | |
|---|---|---|---|---|---|
| TMT-A | 41 ± 20 | 41 ± 19 | 36 ± 15 | 45 ± 22 | 0.382 |
| TMT-B | 106 ± 67 | 105 ± 61 | 90 ± 39 | 118 ± 86 | 0.398 |
| ΔTMT | 64 ± 53 | 63 ± 49 | 54 ± 28 | 73 ± 69 | 0.450 |
| GMV | 647 ± 50 | 654 ± 45 | 655 ± 53 | 635 ± 51 | 0.127 |
| WMV | 641 ± 39 | 634 ± 33 | 641 ± 44 | 647 ± 39 | 0.146 |
| CSFV | 315 ± 38 | 312 ± 37 | 312 ± 42 | 320 ± 37 | 0.388 |
| TICV | 1,603 ± 74 | 1,600 ± 66 | 1,608 ± 84 | 1,603 ± 76 | 0.864 |
| Normalized GMV | 40.4 ± 2.4 | 40.9 ± 2.1 | 40.7 ± 2.6 | 39.6 ± 2.5 | 0.035 |
| Normalized WMV | 40.0 ± 1.6 | 39.6 ± 1.6 | 39.8 ± 1.6 | 40.4 ± 1.6 | 0.054 |
| Normalized frontal GMV | 11.6 ± 0.8 | 11.8 ± 0.7 | 11.8 ± 0.8 | 11.3 ± 0.9 | 0.011 |
| Normalized parietal GMV | 5.1 ± 0.4 | 5.2 ± 0.4 | 5.1 ± 0.4 | 5.0 ± 0.4 | 0.020 |
| Normalized temporal GMV | 6.5 ± 0.5 | 6.6 ± 0.5 | 6.6 ± 0.5 | 6.3 ± 0.5 | 0.016 |
| Normalized occipital GMV | 4.1 ± 0.3 | 4.2 ± 0.4 | 4.1 ± 0.3 | 4.0 ± 0.3 | 0.024 |