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. Author manuscript; available in PMC: 2016 May 6.
Published in final edited form as: Science. 2015 Nov 6;350(6261):aac4250. doi: 10.1126/science.aac4250

Fig. 2. BMAL1 and CLOCK bind to cycling genes at distal regulatory sites.

Fig. 2

(A) Model of transcriptional targets and chromatin modifications for ChIP-seq experiments (top). UCSC genome browser tracks at Nr1d1 (Rev-erbα) locus in β-cells. Maximum track heights within viewable window are indicated to the right of each factor (bottom). (B) Distribution of BMAL1 and CLOCK peaks at cycling and non-cycling gene targets. Binding sites at cycling genes are separated into promoter proximal and distal sites (< and >2kb from TSS of nearest gene, respectively). (C) KEGG ontology terms enriched in cycling and non-cycling BMAL1 and CLOCK target genes.