Table 3.
Crude and corrected differences in HIV-related and mental health outcomes and healthcare utilization between arms at 6 months (primary time-point).
| Intervention | Usual care | Adjusted for design** | Adjusted for design** and missing data*** | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Outcome | n | Mean/% | n | Mean/% | Difference | 95% CI | P value | Difference | 95% CI | P value |
| HIV-related outcomes | ||||||||||
| Percentage adherence, pill count | 86 | 89.2 | 95 | 87.6 | 1.2 | (−4.0, 6.5) | 0.64 | 1.4 | (−3.9, 6.7) | 0.61 |
| Percentage adherence, self-report | 92 | 92.7 | 98 | 93.9 | −0.8 | (−4.6, 3.1) | 0.69 | −1.3 | (−5.8, 3.3) | 0.59 |
| Number of HIV symptoms (range: 0-12) | 92 | 4.5 | 98 | 4.7 | −0.3 | (−1.0, 0.5) | 0.51 | −0.2 | (−0.9, 0.4) | 0.48 |
| Viral load, log-10 | 79 | 1.6 | 98 | 1.9 | −.2 | (−0.5, 0.0) | 0.06 | −0.2 | (−0.6, 0.2) | 0.28 |
| Viral load < 50 copies/ml (%) | 79 | 86.1 | 98 | 76.5 | 9.8 | (−0.9, 20.5) | 0.07 | 9.8 | (−0.9, 20.5) | 0.07 |
| Percentage HIV appointment adherence* | 146 | 81.3 | 151 | 80.1 | 0.8 | (−4.6, 6.2) | 0.77 | 1.2 | (−2.8, 5.3) | 0.56 |
| Physical health-related quality of life (range: 0-100) | 92 | 42.8 | 98 | 43.7 | −1.1 | (−4.4, 2.3) | 0.52 | −1.0 | (−5.0, 3.0) | 0.64 |
| Mental health-related outcomes | ||||||||||
| Depressive severity (range: 0-50) | 92 | 13.5 | 98 | 17.2 | −3.6 | (−5.9, −1.2) | 0.00 | −3.7 | (−5.6, −1.7) | 0.00 |
| Depression remission (%) | 92 | 20.7 | 98 | 17.3 | 0.3 | (−12.1, 12.7) | 0.97 | 12.8 | (1.2, 24.3) | 0.03 |
| Any active suicidality (%) | 92 | 8.7 | 98 | 21.4 | −12.7 | (−23.3, −2.1) | 0.02 | −18.1 | (−29.9, −6.4) | 0.00 |
| Mental health-related quality of life (range: 0-100) | 92 | 41.6 | 98 | 37.6 | 3.7 | (0.3, 7.1) | 0.04 | 3.8 | (−0.1, 7.8) | 0.06 |
| Depression-free days* | 143 | 160 | 137 | 136 | 25 | (1, 49) | 0.04 | 29 | (1, 57) | 0.04 |
| Healthcare utilization | ||||||||||
| Any emergency department visit (%) | 92 | 18.5 | 96 | 20.8 | −5.3 | (−25.2, 14.7) | 0.60 | 0.6 | (−16.0, 17.3) | 0.94 |
| Any hospitalization (%) | 92 | 7.6 | 96 | 4.2 | 3.4 | (−2.4, 9.3) | 0.25 | 5.8 | (−0.9, 12.4) | 0.09 |
*
Over 12 months of study enrollment
**
Via ordinary least squares regression (continuous outcomes) or generalized linear model with identity link and binomial error distribution (binary outcomes), with fixed effects for site and depression treatment experience level and clustered by provider
***
Via linear mixed model (continuous outcomes) or generalized linear model with identity link, binomial error distribution, and inverse probability of observation weighting (binary outcomes), with fixed effects for site and depression treatment experience level and clustered by provider.