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Representative AFM images of the surfaces of corneocytes sampled from patients with AD with 3 different FLG mutation genotypes: +/+, wild-type homozygote; +/−, heterozygote for FLG LOF mutation; −/−, compound heterozygote or homozygote for FLG LOF mutation. On simple inspection, numbers of VPs were clearly increased in carriers of FLG mutations.
