Fig. 4.

Imatinib decreases LPS-induced inflammation when given after injury onset. Mice were challenged with LPS (1.0 mg/kg, it) (vs. PBS) and then received imatinib (75 mg/kg, ip) (vs. vehicle) 4 h later. Lung inflammation was then quantified by BAL total cell counts (A) and BAL neutrophil counts (B). Representative H and E-stained lung sections are shown (C). Each H and E image was obtained from a different animal. SB (n = 3), SB + imatinib (n = 3), LPS (n = 3–6), and LPS + imatinib (n = 3–6). *P < 0.05 compared with SB controls and #P < 0.05 compared with untreated animals.