Fig. 2.

Pressor responses to static contraction before and after simultaneous blockade of ASIC3, P2X, and EP4 receptors. Peak pressor responses to static contraction before and after the combination of PPADS, APETx2, and L161982 injected into the femoral artery (A) and vena cava (B; n = 7). Time courses, plotted second by second, of the changes in MAP averaged for each second of contraction before and after the combination of PPADS, APETx2, and L161982 injected into the femoral artery (C) and vena cava (D) (n = 5). For purpose of illustration, standard error bars were omitted. *P < 0.05, increases in MAP were significantly than their respective baseline levels in A and B. †P < 0.05, significant attenuation in the peak pressor response after drugs compared with that before drugs.