Table 1.
Subject characteristics
| Mild CF | Controls | |
|---|---|---|
| Sex, M:F | 12:7 | 12:7 |
| Age, yr | 30 ± 9 | 30 ± 8 |
| Height, cm | 170 ± 9* | 176 ± 8 |
| Mass, kg | 71 ± 17 | 74 ± 12 |
| BMI, kg/m2 | 24 ± 4 | 24 ± 3 |
| O2 cost diagram, mm | 89 ± 10 | 94 ± 8 |
| mMRC | 0.2 ± 0.4* | 0.0 ± 0.0 |
| FEV1/FVC, % | 75 ± 8* | 80 ± 6 |
| FVC, %predicted | 99 ± 13 | 104 ± 9 |
| FEV1, %predicted | 95 ± 17* | 106 ± 10 |
| FEF25–75, %predicted | 75 ± 33* | 93 ± 20 |
| TLC, %predicted | 102 ± 12 | 101 ± 8 |
| FRC, %predicted | 96 ± 24 | 97 ± 15 |
| PCF, % | 14 ± 6* | 7 ± 6 |
| sRaw, %predicted | 169 ± 47 | 158 ± 32 |
| DLCO, %predicted | 105 ± 18 | 113 ± 15 |
| MIP, cmH2O | 132 ± 38 | 119 ± 37 |
| MEP, cmH2O | 135 ± 54 | 150 ± 55 |
| MVV, l/min | 136 ± 33† | 161 ± 44 |
Values are means ± SD.
CF, cystic fibrosis; BMI, body mass index; mMRC, modified medical research council dyspnea scale; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; FEF25–75, forced expiratory flow between 25 and 75% of FVC; TLC, total lung capacity; FRC, functional residual capacity; PCF, poorly communicating fraction; sRaw, specific airways resistance; DLCO, diffusing capacity of the lung for carbon monoxide; MIP, maximal inspiratory pressure at residual volume; MEP; maximal expiratory pressure at TLC; MVV, maximum voluntary ventilation.
*
Significantly different from control subjects, P < 0.05;
†
P = 0.05.