Table 2.

SIADH diagnostic criteria

Serum Na <135 mmol/l

Plasma osmolarity <275 mOsm/kg

Urine osmolarity >100 mOsm/kg

Hypotonic hyponatremia with clinical euvolemia

Absence of signs of hypovolemia (normal eye pressure values, normal venous pressure, no orthostatism)

Absence of signs of hypervolemia (ascites, edemas)

Urinary Na >40 mmol/l (in the presence of dietary sodium)

No hypothyroidism, no adrenal insufficiency (hypocortisolism) or renal failure

No recent diuretic intake

Absence of physiological stimuli for AVP secretion (recent surgery, severe pain AVP secretion stimulating drugs…)

Table adapted from De las Peñas R et al. Clin Trans Oncol. 2014

AVP arginine vasopressin