Table I.
Post-exposure (days) | Treatment | Total (n) | Alveolitis | Fibrosis | Phagocytosed nanoparticles |
---|---|---|---|---|---|
7 | DM | 7 | 0 (n = 7) | 0 (n = 7) | 0 (n = 7) |
2.5 µg BMWCNT | 8 | 0 (n = 8) | 0 (n = 8) | 2 (n = 8)* | |
2.5 µg FMWCNT | 7 | 0 (n = 7) | 0 (n = 7) | 2 (n = 7)* | |
40 µg BMWCNT | 8 | 0 (n = 4) | 0 (n = 5) | 5 (n = 8)* | |
2 (n = 1) | 3 (n = 2) | ||||
3 (n = 1) | 4 (n = 1) | ||||
4 (n = 2) | |||||
40 µg FMWCNT | 9 | 0 (n = 8) | 0 (n = 8) | 5 (n = 10)* | |
2 (n = 1) | 2 (n = 1) | ||||
56 | DM | 8 | 0 (n = 8) | 0 (n = 8) | 0 (n = 8) |
2.5 µg BMWCNT | 8 | 0 (n = 8) | 0 (n = 8) | 2 (n = 8)*+ | |
2.5 µg FMWCNT | 8 | 0 (n = 8) | 0 (n = 8) | 0 (n = 5)*+ | |
5 (n = 3) | |||||
40 µg BMWCNT | 8 | 0 (n = 3)*+ | 0 (n = 2)*+ | 2 (n = 2)*+ | |
2 (n = 1) | 2 (n = 2) | 4 (n = 3) | |||
4 (n = 4) | 4 (n = 4) | 5 (n = 3) | |||
40 µg FMWCNT | 9 | 0 (n = 9)+ | 0 (n = 8)+ | 0 (n = 1)*+ | |
2 (n = 1) | 2 (n = 6) | ||||
4 (n = 1) | |||||
5 (n = 1) |
BMWCNT, bare multi-walled carbon nanotubes; DM, dispersion medium; FMWCNT, functionalised multi-walled carbon nanotubes.
Values represent histopathology score and inside parentheses the number of animals (n) with that score.
Significant difference between control and MWCNT group at the same post-exposure time.
Significant difference between BMWCNT and FMWCNT groups at an equivalent mass dose at the same post-exposure time.