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. Author manuscript; available in PMC: 2015 Dec 4.
Published in final edited form as: Nanotoxicology. 2013 Mar 19;8(3):317–327. doi: 10.3109/17435390.2013.779757

Table I.

Summary of histopathological findings.

Post-exposure (days) Treatment Total (n) Alveolitis Fibrosis Phagocytosed nanoparticles
7 DM 7 0 (n = 7) 0 (n = 7) 0 (n = 7)
2.5 µg BMWCNT 8 0 (n = 8) 0 (n = 8) 2 (n = 8)*
2.5 µg FMWCNT 7 0 (n = 7) 0 (n = 7) 2 (n = 7)*
40 µg BMWCNT 8 0 (n = 4) 0 (n = 5) 5 (n = 8)*
2 (n = 1) 3 (n = 2)
3 (n = 1) 4 (n = 1)
4 (n = 2)
40 µg FMWCNT 9 0 (n = 8) 0 (n = 8) 5 (n = 10)*
2 (n = 1) 2 (n = 1)
56 DM 8 0 (n = 8) 0 (n = 8) 0 (n = 8)
2.5 µg BMWCNT 8 0 (n = 8) 0 (n = 8) 2 (n = 8)*+
2.5 µg FMWCNT 8 0 (n = 8) 0 (n = 8) 0 (n = 5)*+
5 (n = 3)
40 µg BMWCNT 8 0 (n = 3)*+ 0 (n = 2)*+ 2 (n = 2)*+
2 (n = 1) 2 (n = 2) 4 (n = 3)
4 (n = 4) 4 (n = 4) 5 (n = 3)
40 µg FMWCNT 9 0 (n = 9)+ 0 (n = 8)+ 0 (n = 1)*+
2 (n = 1) 2 (n = 6)
4 (n = 1)
5 (n = 1)

BMWCNT, bare multi-walled carbon nanotubes; DM, dispersion medium; FMWCNT, functionalised multi-walled carbon nanotubes.

Values represent histopathology score and inside parentheses the number of animals (n) with that score.

*

Significant difference between control and MWCNT group at the same post-exposure time.

+

Significant difference between BMWCNT and FMWCNT groups at an equivalent mass dose at the same post-exposure time.