Table 1. Summary of intracellular Gef pharmacokinetic parameters in PC9/G cells treated with Gef (1 μM) alone or combined with Res (40 μM).
Parameters | Gef | Gef + Res |
---|---|---|
Ka (1/h) | 0.30 ± 0.06 | 0.22 ± 0.04 |
Ke (1/h) | 9.41 ± 1.61 | 7.41 ± 0.92 |
AUC (h*nM/mg protein) | 441.3 ± 52.9 | 654.4 ± 57.3* |
CL (mg protein /hr) | 2.27 ± 0.27 | 1.27 ± 0.19* |
Tmax (h) | 1.55 ± 0.18 | 1.17 ± 0.15 |
Cmax (nM/mg protein) | 28.45 ± 1.19 | 55.04 ± 1.95** |
Data are presented as means ± SD (n = 3). *P < 0.05, **P < 0.01 compared with Gef treatment alone.