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. 2015 Dec 4;5:17730. doi: 10.1038/srep17730

Table 1. Summary of intracellular Gef pharmacokinetic parameters in PC9/G cells treated with Gef (1 μM) alone or combined with Res (40 μM).

Parameters Gef Gef + Res
Ka (1/h) 0.30 ± 0.06 0.22 ± 0.04
Ke (1/h) 9.41 ± 1.61 7.41 ± 0.92
AUC (h*nM/mg protein) 441.3 ± 52.9 654.4 ± 57.3*
CL (mg protein /hr) 2.27 ± 0.27 1.27 ± 0.19*
Tmax (h) 1.55 ± 0.18 1.17 ± 0.15
Cmax (nM/mg protein) 28.45 ± 1.19 55.04 ± 1.95**

Data are presented as means ± SD (n = 3). *P < 0.05, **P < 0.01 compared with Gef treatment alone.