Table 1. Pairwise comparisons of Schistosoma haematobium (Sh) kinase sequences with orthologs in S. mansoni (Sm) and human.

Kinase groupa	Length ratio Sh/Sm [SD]	S. mansoni% identity [SD]	S. mansoni% similarity [SD]	H. sapiens% identity [SD]	H. sapiens% similarity [SD]
CMGC	1.00 [0.08]	91.87 [6.10]	94.42 [4.96]	61.04 [8.93]	75.91 [7.15]
CAMK	1.00 [0.08]	87.89 [8.48]	91.48 [6.55]	54.57 [13.91]	71.31 [10.79]
AGC	0.99 [0.19]	91.20 [5.91]	93.78 [4.94]	52.40 [13.22]	68.66 [11.15]
Other	0.98 [0.17]	87.18 [8.46]	90.28 [7.77]	43.54 [12.06]	62.11 [10.87]
TK	0.99 [0.11]	87.66 [8.18]	91.12 [6.92]	45.74 [6.50]	63.68 [6.46]
STE	1.04 [0.22]	90.75 [6.89]	93.21 [6.22]	56.94 [12.14]	72.62 [10.73]
TKL	1.01 [0.08]	88.59 [6.33]	92.01 [5.67]	45.29 [9.95]	63.58 [8.68]
CK1	0.98 [0.14]	85.05 [8.21]	87.85 [7.94]	62.61 [11.20]	76.30 [8.58]
RGC	1.02 [0.19]	85.30 [6.00]	87.53 [6.86]	50.43 [5.36]	66.70 [5.38]
PKL	1.07 [0.12]	88.45 [3.92]	91.53 [4.01]	43.55 [6.34]	60.90 [5.82]
Unclassified	1.06 [0.11]	82.50 [14.84]	88.92 [9.30]	35.12 [7.76]	58.10 [3.93]

Average length ratios, identity and similarity values are indicated. Amino acid sequence conservation between S. haematobium and S. mansoni was observed for all kinase groups. Predicted sequences had very similar lengths. The comparison with human homologs showed moderate to low identities and similarities. Average and standard deviation [SD] values were calculated based on the number of predicted S. haematobium sequences in each kinase group.

^aCMGC = Cyclin-dependent kinases (CDKs), mitogen-activated protein kinases (MAP kinases), glycogen synthase kinases (GSKs) and CDK-like kinases; CAMK = Ca²⁺/calmodulin-dependent kinases; AGC = Nucleoside-regulated kinases; TK = Tyrosine kinases; STE = MAPK cascade kinases; TKL = Tyrosine kinase-like kinases; CK1 = Casein kinase 1 kinases; RGC = receptor guanylate cyclases; PKL = Protein kinase-like kinases.