Table 4. Age- and sex- and multivariable-adjusted^a associations between BMI at age 20, change in BMI since age 20^b and risk of head-neck cancer subtypes; Netherlands Cohort Study, 1986–2006.

^aAdjusted for age (years), sex, cigarette smoking (status (never/former/current), frequency (number of cigarettes per day; continuous, centered), duration (number of years; continuous, centered)), and alcohol consumption (grams ethanol per day; continuous).

^bCategories of BMI at age 20 and change in BMI (kg/m²).

^cOCC: oral cavity cancer; OHPC: oro-/hypopharyngeal cancer; LC: laryngeal cancer.

^dAbbreviations: RR: incidence rate ratio; CI: confidence interval.

^eTests for dose-response trends were assessed by fitting ordinal exposure variables as continuous terms in the Cox proportional hazards model.

^fP Value for interaction between sex and BMI at baseline (continuous), based on cross-product terms in the Cox proportional hazards model and Wald test.

^gChange in BMI since age 20 years was additionally adjusted for BMI at age 20 years.

^hP < 0.05.

ⁱThe proportional hazards assumption was possibly violated for the exposure variable in this analysis; there was no statistically significant interaction between the exposure variable and time.

^jThe proportional hazards assumption was possibly violated for the exposure variable in this analysis; there was a statistically significant interaction between the exposure variable and time.