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. 2015 Dec 4;5:17476. doi: 10.1038/srep17476

Figure 3. Overexpression of Gαtransducin switches histamine potentiation into inhibition of GR activity.

Figure 3

HEK-293T cells co-transfected with TAT3-Luc, GR and H1R coding constructs were transfected or not with Gαtransducin (Gαt), as indicated. Luciferase activity was determined as described in the methods section. Results are mean+/−SEM of three independent experiments performed in triplicates. Inset: HEK-293T cells co-transfected with TAT3-Luc, GR and H1R constructs were transfected with different amounts of Gαt, and subjected to different treatments, as indicated. Luciferase activity was determined as described in the methods section. Results are mean+/−SEM of three independent experiments performed in triplicates. **p < 0.01; ***p < 0.001.