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. 2015 Dec 4;5:17798. doi: 10.1038/srep17798

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Copyright © 2015, Macmillan Publishers Limited

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Panels (A,B) show the isolated islets before and after LPS stimulation, respectively. The concentrations of pro-inflammatory cytokines (IL-6 and TNF-α) in the conditioned media from islet cultures with stimulation of LPS were determined by ELISA. The levels of IL-6 (C) and TNF-α (D) in the septic WT and SP-D KO mice significantly increased at 12 h and 24 h after stimulation with LPS as compared with controls. The levels of IL-6 and TNF-α were significantly increased at 12 h and 24 h after LPS stimulation in the conditioned medium of islets of SP-D KO mice compared to WT mice. Graphs represent the mean ± SEM. *p < 0.05, **p < 0.01. (n = 3 independent experiments).