Table 1.
Uterine Pathology in CD1 Mice.
|
Exposure group: |
BPA (ppm) |
EE (ppm) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.03 | 0.3 | 3 | 30 | 300 | 0.0001 | 0.001 | 0.01 | |
| PND 21 | |||||||||
| n= | 5 | 6 | 5 | 7 | 7 | 5 | 5 | 6 | 5 |
| Distended glands | 0 (0%) | 1 (17%) | 0 (0%) | 0 (0%) | 1 (14%) | 1 (20%) | 1 (20%) | 0 (0%) | 2 (40%) |
| Cysts | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| PND 49 | |||||||||
| n= | 9 | 8 | 11 | 8 | 5 | 10 | 10 | 5 | 7 |
| Distended glands | 2 (22%) | 1 (13%) | 4 (36%) | 5 (63%) | 2 (40%) | 2 (20%) | 2 (20%) | 1 (20%) | 2 (29%) |
| Cysts | 0 (0%) | 0 (0%) | 1 (9%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (20%) | 0 (0%) |
| PND 90 | |||||||||
| n = | 10 | 11 | 12 | 10 | 14 | 13 | 8 | 11 | 9 |
| Distended glands | 7 (70%)a | 7 (64%)a | 6 (50%) | 6 (60%)a | 9 (64%)a | 11 (85%)a | 6 (75%)a | 7 (64%)a | 4 (44%) |
| Cysts | 0 (0%) | 2 (18%) | 1 (8%) | 1 (10%) | 2 (14%) | 0 (0%) | 1 (13%) | 0 (0%) | 1 (11%) |
| Gland nest density (nest/mm2±SE) | 0.03±0.02 | 0.02±0.01 | 0.08±0.03 | 0.02±0.01 | 0.11±0.04 | 0.13±0.05 | 0.01±0.01 | 0.03±0.03 | 0.09±0.06 |
a
P<0.05 by χ2 test for trend across PNDs in exposure group for increases in distended glands.