Table 2. Metabolic activities of the individual CYP enzymes in human livers (n = 78).
| Probe drug (Metabolite) | VM (pmol/min/mg protein) | VL (nmol/min/g liver) | ||
|---|---|---|---|---|
| CYP1A2 | phenacetin (paracetamol) | Median | 677.94 | 22.12 |
| Range | 97.37–2368.14 | 3.16–119.91 | ||
| 95% PI | 169.20–1344.69 | 4.77–71.38 | ||
| CYP2A6 | coumarin (7-OH-coumarin) | Median | 267.92 | 8.19 |
| Range | 7.20–788.56 | 0.22–47.08 | ||
| 95% PI | 12.19–689.73 | 0.35–42.83 | ||
| CYP2B6 | bupropion (4-OH-bupropion). | Median | 46.67 | 1.68 |
| Range | 11.75–290.89 | 0.28–17.63 | ||
| 95% PI | 12.16–151.14 | 0.31–11.31 | ||
| CYP2C8 | paclitaxel (6-OH- Paclitaxel) | Median | 31.50 | 0.96 |
| Range | 2.74–87.23 | 0.12–7.71 | ||
| 95% PI | 4.34–74.27 | 0.17–4.81 | ||
| CYP2C9 | tolbutamide.(4-OH-tolbutamide) | Median | 222.70 | 7.29 |
| Range | 70.00–461.07 | 1.51–37.61 | ||
| 95% PI | 76.17–391.49 | 1.96–34.92 | ||
| CYP2C19 | omeprazole (4-OH-omeprazole) | Median | 97.62 | 3.64 |
| Range | 1.40–325.03 | 0.14–19.58 | ||
| 95% PI | 9.98–274.83 | 0.51–17.62 | ||
| CYP2D6 | dextromethorphan (3-methoxymorphinan) | Median | 68.16 | 2.11 |
| Range | 4.93–222.34 | 0.19–14.49 | ||
| 95% PI | 9.06–190.03 | 0.30–14.15 | ||
| CYP2E1 | chlorzoxazone (6-OH-chlorzoxazone) | Median | 486.92 | 16.03 |
| Range | 140.81–1604.44 | 3.28–74.52 | ||
| 95% PI | 198.24–1061.97 | 4.60–69.28 | ||
| CYP3A4/5 | midazolam (1-OH-midazolam) | Median | 836.56 | 29.05 |
| Range | 57.24–4144.93 | 2.93–251.26 | ||
| 95% PI | 178.15–2967.83 | 3.55–217.79 |
VM: metabolic rate of the individual CYP enzyme based on per mg microsomal protein; VL: metabolic rate of the individual CYP enzyme based on per gram liver tissue; PI: percentile interval.