Table 3. Values for hepatic clearance of tolbutamide 4-hydroxylation and their variations.

	n	Range	Fold change (Max/Min)	Mean ± SD	95% PI	Fold change (95% PI)
Predicted CLH (ml/min/kg)
Method A	78	0.011–0.559	50.8	0.113 ± 0.095	0.012–0.365	30.4
Method B	78	0.027–0.341	12.6	0.113 ± 0.065	0.038–0.311	8.2
Method C	78	0.018–0.353	19.6	0.113 ± 0.064	0.026–0.268	10.3
Method D	78	0.093–0.142	1.5	0.113 ± 0.011	0.095–0.139	1.5
Method E	78	0.1128–0.1130	1.0	0.113 ± 0.000	0.1128–0.1130	1.0
Method F	78	0.079–0.161	2.0	0.116 ± 0.019	0.082–0.155	1.9
Method G	78	—	—	0.113	—	—
Observed CLH (ml/min/kg)
Back et al.47	7			0.260 ± 0.100
Back et al.47	6			0.226 ± 0.024
Back et al.47	6			0.239 ± 0.050
Miners et al.48	6			0.171a
Wilner et al.49	6			0.147 ± 0.013
Wing et al.50	7			0.159a

Method A used the individual values for each parameter (MPPGL, CL_int, in vitro, LW, Q_H and BW) for 78 livers. Method B used the individual MPPGL value and the mean values for the remaining four parameters. Similar to method B, method C, D, E and F used the individual CL_{int, in vitro}, LW, Q_H or BW value, respectively, and the mean values for the remaining four parameters. Method G used the mean value of the five parameters for that particular liver.

^aNo SD is available. PI: percentile interval.