Table 2.
Validation of top SNP rs5914778 in southern and northern regions of China
| Central meta (discovery + central validation)a | Southern validationb | Northern validationc | Meta (discovery + central + southern validations)d | Meta (discovery + central + southern + northern validations)e | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker | Gene symbol | PVAL (FE) | OR (FE) | PVAL | OR | MAF (case) | MAF (control) | PVAL | OR | MAF (case) | MAF (control) | PVAL (FE) | I 2 (FE) | PVAL (Het) | OR (FE) | PVAL (FE) | I 2 (FE) | PVAL (Het) | OR (FE) |
| rs5914778 | LINC01420 | 1.00 × 10–8 | 1.32 | 5.31 × 10–5 | 1.51 | 0.352 | 0.265 | 3.28 × 10–1 | 0.85 | 0.252 | 0.284 | 5.26 × 10–12 | 0 | 4.62 × 10–1 | 1.35 | 1.22 × 10–10 | 65.3 | 3.44 × 10–2 | 1.31 |
aConsists of 2173 cases and 2869 controls
bConsists of 1012 cases and 335 controls
cConsists of 274 cases and 133 controls
dConsists of 3185 cases and 3204 controls
eConsists of 3459 cases and 3337 controls
FE fixed effects, Het heterogeneity, I 2 heterogeneity statistic, MAF minor allele frequency, OR odds ratio, PVAL P value, SNP single nucleotide polymorphism