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The CD4/CD8 ratio reduction is observed in CL sick dogs, regardless the diet. Values indicate the CD4/CD8 ratio observed in healthy dogs, in sick dogs at T0, T3, T6 and T12 in SD Group (pharmacological treatment alone) and IMMD Group (pharmacological treatment and immune-modulating diet), as indicated. The column of Healthy Dogs refers to the means ± SD values of normal range (see material and methods) of CD4/CD8 ratio in healthy controls. Results were considered significant at p < 0.05
