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. 2015 May 7;6(5):e1736. doi: 10.1038/cddis.2015.102

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Myristoylation is required for P36 proapoptotic effect in ALK-positive tumor cells. Cost ALCL cells were either incubated 1 h at 37 °C (a and b) or transfected using an Amaxa Nucleofector device (c and d) with biotin-coupled P36, either N-myristylated (P36-myr-biot) or unmyristylated (P36-biot). The peptides were visualized with streptavidin-FITC after cell fixation and permeabilization. Four-panel composites show Nomarski interference contrast (gray), peptide (green), cell nuclei (DAPI, blue) or a merge of all three (bottom right panels). (e) Cell viability following incubation or transfection with peptides was assayed after 48 h of treatment. The graph represents one of two independent experiments