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. 2015 May 7;6(5):e1736. doi: 10.1038/cddis.2015.102

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Combined cytotoxic effect of P36 and PF on ALK-positive tumor cells. Cost ALCL (left) or SH-SY5Y neuroblastoma (right) cells were incubated for 48 h with increasing doses of P36 (0–30 μM) or PF (0–20 μM) or a combination of both drugs as indicated. (a–d) Dose–response curves of P36 and PF on Cost (a and b) and SH-SY5Y (c and d) cell viability, respectively. (e–h) Viability curves for Cost (e and f) and SH-SY5Y (g and h) treated with a constant dose of either P36 or PF close to the IC₅₀ while varying the dose of the other drug. (i and j) Normalized isobolograms drawn for ED₈₀ indicate a synergistic trend (i, Cost) or an additive effect (j, SH-SY5Y) of P36 and PF combination