Table 1. List of P36-interacting proteins that are identical or similar in Cost ALCL and SH-SY5Y neuroblastoma cell lines.
| Cell lines | Protein symbol | Cell process and function |
|---|---|---|
| Interaction with the p53 gene/protein or p53-dependent signaling pathways | ||
| Cost and SH-SY5Y | SUB1 (PC4) | Transcriptional coactivator for p53, neural gene silencing |
| Cost and SH-SY5Y | SSBP1 | p53-dependent DNA damage |
| Cost and SH-SY5Y | HRNR | Skin protein, member of S100 family, elevated in various tumors |
| Cost and SH-SY5Y | XRCC5 (KU80) | RNA helicase, repair of DNA ds breaks by NHEJ and V(D)J recombination |
| Cost and SH-SY5Y | EEF1A1 | Elongation factor, protein biosynthesis |
| Regulation of pre-mRNA splicing | ||
| Cost and SH-SY5Y | LUC7L2 | Pre-mRNA splicing, recognition of non-consensus splice donor sites |
| Cost | LUC7L3 | Pre-mRNA splicing, formation of spliceosome |
| Cost | SFRS3 | Pre-mRNA splicing, neural differentiation, proto-oncogene |
| Cost | SFRS11 | Pre-mRNA splicing, neural differentiation |
| Cost | DDX46 | RNA helicase, pre-mRNA splicing |
| SH-SY5Y | DDX5 | RNA helicase, p53-dependent DNA damage and apoptosis, neural differentiation |
| SH-SY5Y | DDX39 | RNA helicase, pre-mRNA splicing |
| SH-SY5Y | SFRS2 | Pre-mRNA splicing, cisplatin-mediated apoptosis |
| SH-SY5Y | SFRS7 | Pre-mRNA splicing, neural gene silencing |
| SH-SY5Y | U2AF1 | Pre-mRNA splicing, spliceosome |
| SH-SY5Y | U2AF2 | pre-mRNA splicing, spliceosome |
P36-interacting proteins were classified in two functional families: proteins potentially interfering with p53 tumor suppressor, and mRNA splicing factors. Information on genes' function was retrieved from Genecards (www.genecards.org)