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P53 interacts with acetylated HDAC1 after heat stress. (a) HCT116 cells were treated with heat shock at 42 °C for 1 h and then recovered at 37 °C for 2 h. After treatment, the cells were subjected to immunoprecipitation by using the p53 antibody. The p300, SIRT1, ac-HDAC1 and HDAC1 levels were examined by western blotting. (b) Model depicting the dynamic regulation of p53 and HDAC1 acetylation upon cellular stress
