Figure 4.

4Ig treatment reduces ischemic damage and promotes functional recovery after MCAO. Rats were subjected to MCAO followed by treatment with 4Ig (10 mg/kg, tail vein injection) or PBS (Control). (a) Behavioral assessment was performed over a 7-day period. This revealed that treatment with 4Ig led to a significant improvement of functional scores when compared with controls (*P<0.05). (b) Representative TTC-stained coronal brain sections (2 mm) from each group. (c) Infarct size was determined by TTC staining and expressed as the percentage of actual infarct volume in the total cerebral volume. Infarct size was significantly lower in 4Ig-treated rats when compared with controls. (*P<0.01). (d) Brain edema was determined by calculating the percentage of increase in ischemic versus healthy cerebral hemisphere. Treatment with 4Ig significantly reduced edema size (*P<0.05)