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. 2015 May 21;6(5):e1764. doi: 10.1038/cddis.2015.117

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Che-1 modulates p53 target selectivity. (a) The p53 consensus binding motif was identified de novo by analyzing the sequences of peaks deriving from a p53-specific ChIP-seq with HCT116 cells transiently transfected with siRNA GFP (siControl) or siRNA Che-1 (siChe-1) and analyzed 4 h after IR treatment (20 Gy) using the program MEME. (b) Venn diagrams were obtained by intersection of all p53-bound DNA fragments in HCT116 cells treated as described in (a and c). Tag density correlation between the two peak sets siControl (control siRNA) and siChe-1 (Che-1 siRNA). (d) GO term networks constructed by REViGO. Node size indicates frequency of term in database, node color intensity reflects increasing significance as by q-values, and edge weight indicates term similarity. (e) ChIP-Seq data from the indicated gene promoters showing the occupancy of p53 in samples as described in (b)