Table 1a. VPA treatment responsive selected GO categories for downregulated differentially expressed genes (P<0.05).
| Term | Count | P-value | Genes |
|---|---|---|---|
| Regulation of transcription, DNA-dependent | 105 | 4.82E–06 | REST, RORA, ZNF254, HOXC6, TDGF3, GATA6, TDGF1, OLIG2, MLL3, PITX2, NODAL, EMX2, ZNF814, EOMES, SUZ12, HES5, SOX7, LIN28A, NR2C2, ARX, FOXH1, LHX9, DNMT3A, SALL4, FOXA2, NR6A1, PAX3, GLI2, POU5F1, HEY2, ZNF720, SOX10, NANOG, DMRT3, OTX2, RUNX1T1, SPEN, HAND1, ISL1, POU5F1B, ATRX, RBAK, THRAP3, PBX2 |
| Embryonic morphogenesis | 26 | 3.44E–04 | RBP4, FOXA2, PAX3, GLI2, TDGF3, SPRY2, HAND1, PRKRA, TDGF1, CEP290, NODAL, EOMES, PCDH8, CFC1, DKK1, SALL4, GNAQ, HOXB6, LRP6, PTCH1, MAB21L2, PBX2 |
| Lung development | 11 | 0.004697 | SPRY2, RBP4, FOXA2, PDGFA, GATA6, DHCR7, NODAL, VEGFA, GLI2, FOXP1, KDR |
| Regulation of neurogenesis | 13 | 0.026608 | PHOX2B, NBN, BMP2, FOXA2, REST, ISL1, GLI2, RUFY3, HES5, CCND2, NUMB, NEFM, ASPM |
| Forebrain development | 16 | 7.60E–04 | OTX2, EMX2, GLI2, ISL1, AHSG, ARX, SALL3, ATRX, FEZF2, DKK1, GNAQ, NUMB, PAFAH1B1, LRP8, RELN, ASPM |
| Neuron differentiation | 32 | 8.12E–04 | FGFR1, FOXA2, ONECUT2, GRIN3A, PAX3, RORA, GLI2, PTEN, CXCL12, KLHL1, ARX, KAL1, NUMB, CEP290, OLIG1, PAFAH1B1, OLIG2, RET, BHLHE22, OTX2, EMX2, LIFR, ISL1, CDKN1C, SALL3, FEZF2, EPHA4, ADM, GNAQ, HES5, VEGFA, RELN |
| Cerebral cortex development | 6 | 0.008017 | ARX, EMX2, LRP8, PAFAH1B1, RELN, AHSG |
| Telencephalon development | 7 | 0.038287 | ARX, SALL3, EMX2, LRP8, PAFAH1B1, RELN, AHSG |
The selected genes were represented corresponding to the respective GO